More specifically, the effect achieved after one takes pills of DXM and washes them down with alcohol. More severe cases can also merit the inclusion of the adverb "infragibly" (Refrencing the hulk-esque character of the "Justice Friends" cartoon usually shown with "Dexter's Lab").
Possible origin may be that one developes impairments of speech and vocabulary, therefor sounding a bit like him.
A swear word first used in 1994 on the late night talk show LATE NITE WITH CONAN O'BRIEN/NBC/1993+ According to its creator, Conan O'Brien, Krunk was "America's newest swear word...so new that the networks don't know whether to censor it or not!"
Example: Phrases like "What the krunk do you want" and "It's none of your krunking business!" were exchanged by both guests and host of the show.