A methamphetamine user.

A methamphetamine user. The term was coined for the sleep deprivation crystal meth addicts usually undergo. Some users would stay up for two weeks at a time so came the phrase 'two weekers' which eventually became tweeker.

Someone addicted to meth. Usually they are untrustworthy, incureable, and totally not themselves. When one does meth, a profound change occurs. The person is no longer themself, and will now steal anything from anyone to get money for meth, and is often alone due to the extreme paranoia induced by the comedown of the meth. First tweekers start by doing lines, then by smoking meth, then freebasing it, then by straight up injecting it. Once they inject speed, they are officially hopeless tweekers. Generally, when such means are taken to get high, the tweeker is now homeless, and disowned by his/her family, really underweight due to lack of food and sleep, and has a poor facial complexion also due to lack of food and sleep. Often, when tweekers are in such state of despair, they will do anything- and I mean anything- to get their meth. Oftentimes they will suck dick (no matter if it's a dude or a chick) and even get raped up the ass for meth. Sometimes they will sell stolen merchandise for meth. Sometimes they will even mug their own family for meth. They can be that desparate.

A person addicted to some type of speed whose favorite hobbies include taking things apart beyond recognition, sitting by the backdoor with a large knife, 'dieting', watching American Idol, and staying up for up to 2 weeks strait. They can some times be dangerous, but are usually a lot of fun.

The homeless, meth addict, usually skinny, smelly, who is riding a 10,000 racing mountain bike, dressed in rags, malnourished, at three oclock in the morning through the streets of sunnyslope, (phx az)with a 10 foot antique brass lamp over there shoulder on their way to the (meth)dope mans house to score another $20 bag, if you watch him long enough you will most likely see him look over his shoulder to see if "they" are close behind, you will likely see him stop at each and every dumpster that looks like it might have anything at all in it.

Or spelled as tweaker, refers to someone who does meth, or cocaine.

Could also refer to abusing Adderall, or Dex, or similar drugs prescribed to treat ADHD. Because the ingredients are the same, Adderall is just a really really low dosage of it. Abusing get's you the same high, which is tweeking.

A person who has worked their way to the second highest level of their methamphetamine career, tweekers have poor hygiene. The only level above a tweeker is a Cook who carries God like status among tweeker because the cook manufactures the crystal death that they all soo much love.

An inhibitant of Co. Co. County, SF Bay Area. (see Danvillians) REPRESENT! Usually found skulking in bushes, trees or they dark garages the call, "Their Castles". Most common traits include: haircuts without scissors, surgery without a scalple, and spending countless hours of the night playing window nintendo! Some tweekers are a bit more fortunate, their game systems have been upgraded to home surveillance systems. Their mission in life is to obtain and comsume as much FUCKING CRANK AS WE POSSIBLY CAN!!!
Smoke crank! Fuckers.....

A person, often a crystal meth user, who does completes every thing he/she begins far beyond the point of finished.